Chronic Nitric Oxide Deficiency and Progression of Kidney Disease after Renal Mass Reduction in the C57Bl6 Mouse
نویسندگان
چکیده
منابع مشابه
Chronic nitric oxide deficiency and progression of kidney disease after renal mass reduction in the C57Bl6 mouse.
BACKGROUND/AIMS the C57Bl6 mouse is resistant to chronic kidney disease (CKD) induced by reduction of renal mass (RRM). Nitric oxide (NO) deficiency exacerbates CKD progression so this study investigated whether combination of RRM and NO deficiency would render the C57Bl6 mouse vulnerable to CKD. METHODS we used wild-type (WT) mice with RRM, chronic NO synthase (NOS) inhibition and a combinat...
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ژورنال
عنوان ژورنال: American Journal of Nephrology
سال: 2010
ISSN: 1421-9670,0250-8095
DOI: 10.1159/000322106